Guadalupe on Main is a gluten-friendly Mexican restaurant and craft cocktail bar located on Main Street in Mesa. The restaurant specializes in flavors from Jalisco and operates as a craft kitchen with cocktails. Recently recognized by Phoenix Magazine as Best New Restaurant and Best Mexican Restaurant in their 2025 Best of the Valley awards. The establishment features a Chef's Test Kitchen and offers both dining and bar experiences.
Happy Hour
Specials
1/2 Bottles of Wine $1 Off Tacos Dorados $2 Off Drafts $3 Off Appetizers $4 Off Glasses of Wine $5 Select Cocktails
Amenities
Happy hours near Mesa
BJ's Restaurant & Brewhouse - Mesa
BJ's Restaurant & Brewhouse has been a Mesa dining staple since 2005, specializing in deep dish pizza and handcrafted beer. This brewery and restaurant combines casual dining with an extensive selection of house-made brews. The establishment offers a relaxed atmosphere perfect for enjoying both comfort food classics and craft beverages. Happy hour deals are available in the bar and patio areas, making it an ideal spot for after-work gatherings.
12 West Brewing - Mesa
12 West Brewing Co. is an Arizona-based brewery in Downtown Mesa. It offers craft beers brewed in-house alongside a full food menu. Known for its creative small-batch beers and community-focused spaces, it features indoor and outdoor seating, live music, and events. The brewery blends a relaxed atmosphere with quality brews and locally inspired dishes.
Uncle Bear's Grill & Tap - Mesa Greenfield
Uncle Bear's Grill & Tap is a casual dining establishment and bar featuring craft beer and grill fare in Mesa. The restaurant offers a family-friendly atmosphere with a full menu that includes hot dogs, lunch items, and various grilled options. With multiple locations across the Phoenix metro area, Uncle Bear's focuses on craft beer selections alongside their kitchen offerings. The venue provides both dine-in service and takeout options for guests.
Arizona Distilling Co
Arizona Distilling Co. is a craft distillery located in Tempe, Arizona, dedicated to producing high-quality, small-batch spirits. They offer a range of products, including award-winning whiskeys, vodkas, and gins, all made using locally sourced ingredients and traditional distillation methods. With a commitment to excellence and a passion for craftsmanship, Arizona Distilling Co. provides a unique and authentic spirit experience, capturing the essence of Arizona's rich heritage and culture. Visitors can enjoy tours and tastings to learn more about the distillation process and sample their exceptional products.
The Hub Grill & Bar - Sossaman
The Hub Grill & Bar is a casual neighborhood restaurant and bar serving American comfort food with Southwest influences. The multi-location establishment features an extensive tap selection with domestic and craft beers, full bar service, and a menu that includes burgers, pizza, appetizers, and fish and chips. The venue offers gluten-free options and maintains a family-friendly atmosphere with kids eat free nights. Known for its consistent daily specials and happy hour programming, The Hub provides a relaxed setting for both dining and drinks.
The Hub Grill & Bar - Stapley
The Hub Grill & Bar is a casual neighborhood restaurant and bar serving American comfort food with Southwest influences. The multi-location establishment features an extensive tap selection with domestic and craft beers, full bar service, and a menu that includes burgers, pizza, appetizers, and fish and chips. The venue offers gluten-free options and maintains a family-friendly atmosphere with kids eat free nights. Known for its consistent daily specials and happy hour programming, The Hub provides a relaxed setting for both dining and drinks.
Page Updated: 05/16/2026
*Prices and specials are subject to change at any time