Guadalupe on Main is a gluten-friendly Mexican restaurant and craft cocktail bar located on Main Street in Mesa. The restaurant specializes in flavors from Jalisco and operates as a craft kitchen with cocktails. Recently recognized by Phoenix Magazine as Best New Restaurant and Best Mexican Restaurant in their 2025 Best of the Valley awards. The establishment features a Chef's Test Kitchen and offers both dining and bar experiences.
Happy Hour
Specials
1/2 Bottles of Wine $1 Off Tacos Dorados $2 Off Drafts $3 Off Appetizers $4 Off Glasses of Wine $5 Select Cocktails
Amenities
Happy hours near Mesa
Arizona Rebel Republic
Arizona Rebel Republic is a casual bar and grill with locations in Mesa and Lake Havasu City, built around an American comfort food menu and a full bar with a lineup of house cocktails and specialty drinks. The atmosphere leans energetic and unpretentious, with a concept designed around gathering, sharing food, and staying awhile. A happy hour program runs across multiple windows throughout the week, making it a natural stop for after-work crowds in the Southeast Valley.
Espiritu
Espiritu Cocktails + Comida, located in Mesa, AZ, offers a vibrant dining experience with a focus on cocktails and Mexican cuisine. Opened by the teams behind Tacos Chiwas and Bacanora, Espiritu was named one of the best new restaurants in the country by Eater in 2022. The restaurant, known for its innovative take on Sonoran dishes and a lively atmosphere, offers a curated food menu and an extensive drinks list, earning acclaim for both its culinary and cocktail experiences.
Diamond’s Sports Grille
Diamond’s Sports Grille is Mesa’s go-to destination for sports fans, offering a relaxed atmosphere filled with flat-screen TVs and plenty of energy. Known for its classic American comfort food, the menu features crowd favorites like burgers, sandwiches, and wings, all served with friendly service. With a legacy tied to baseball history and a welcoming neighborhood vibe, it’s the perfect spot to catch a game with friends or unwind over hearty food and drinks.
The Hub Grill & Bar - Sossaman
The Hub Grill & Bar is a casual neighborhood restaurant and bar serving American comfort food with Southwest influences. The multi-location establishment features an extensive tap selection with domestic and craft beers, full bar service, and a menu that includes burgers, pizza, appetizers, and fish and chips. The venue offers gluten-free options and maintains a family-friendly atmosphere with kids eat free nights. Known for its consistent daily specials and happy hour programming, The Hub provides a relaxed setting for both dining and drinks.
Copper State Taphouse
Copper State Taphouse in Mesa offers a welcoming space to enjoy one of its 29+ rotating craft beers on tap, featuring selections from Arizona breweries and beyond. The cozy yet modern setting makes it a perfect spot to gather with friends, catch a game on TV, or play a board game in the lounge. A carefully curated food menu, with options like pizza, subs, and handcrafted sandwiches, complements the wide variety of brews. With its relaxed vibe and thoughtful offerings, it’s an ideal destination for beer lovers looking to unwind.
Pedal Haus Brewery - Mesa
Pedal Haus Brewery in Downtown Mesa offers a range of craft beers, from light lagers to barrel-aged stouts, alongside a full bar and elevated pub fare. The venue features a spacious patio and is ideal for private events and celebrations. Located on Main Street, it provides convenient parking options and a vibrant atmosphere for dining and drinks.
Page Updated: 05/16/2026
*Prices and specials are subject to change at any time