Guadalupe on Main is a gluten-friendly Mexican restaurant and craft cocktail bar located on Main Street in Mesa. The restaurant specializes in flavors from Jalisco and operates as a craft kitchen with cocktails. Recently recognized by Phoenix Magazine as Best New Restaurant and Best Mexican Restaurant in their 2025 Best of the Valley awards. The establishment features a Chef's Test Kitchen and offers both dining and bar experiences.
Happy Hour
Specials
1/2 Bottles of Wine $1 Off Tacos Dorados $2 Off Drafts $3 Off Appetizers $4 Off Glasses of Wine $5 Select Cocktails
Amenities
Happy hours near Mesa
Rebel Wine Lounge
Rebel Wine Lounge in Downtown Mesa offers an elegant yet approachable setting for wine lovers to gather and unwind. With a thoughtfully curated selection of wines from around the world, guests can enjoy unique pours alongside a menu of shareable bites. The chic lounge atmosphere makes it an ideal spot for date nights, casual meetups, or special celebrations. Pairing style with comfort, Rebel Wine Lounge is quickly becoming a favorite destination for wine enthusiasts in the Valley.
Worth Takeaway
Worth Takeaway in Mesa, AZ, established in Downtown Mesa at the start of 2016, is celebrated for crafting memorable experiences through chef-driven food in a welcoming package. Known for its craft sandwiches, the restaurant also offers rotating dinner and dessert specials, catering to a wide range of tastes including vegetarian and vegan options. With a commitment to community and quality, Worth Takeaway aims to serve its guests with high-quality, approachable food, highlighting the importance of local partnerships and sustainable practices.
Uncle Bear's Grill & Tap - Mesa Greenfield
Uncle Bear's Grill & Tap is a casual dining establishment and bar featuring craft beer and grill fare in Mesa. The restaurant offers a family-friendly atmosphere with a full menu that includes hot dogs, lunch items, and various grilled options. With multiple locations across the Phoenix metro area, Uncle Bear's focuses on craft beer selections alongside their kitchen offerings. The venue provides both dine-in service and takeout options for guests.
12 West Brewing - Mesa
12 West Brewing Co. is an Arizona-based brewery in Downtown Mesa. It offers craft beers brewed in-house alongside a full food menu. Known for its creative small-batch beers and community-focused spaces, it features indoor and outdoor seating, live music, and events. The brewery blends a relaxed atmosphere with quality brews and locally inspired dishes.
Los Sombreros - Mesa
Los Sombreros in Mesa offers authentic Mexican cuisine in a relaxed, vibrant setting inspired by the flavors of central and southern Mexico. The menu features traditional dishes like enchiladas, tacos, and mole, paired with handcrafted margaritas and a curated tequila selection. A spacious patio and colorful décor make it a welcoming spot for casual meals, happy hour, and gatherings with friends or family.
Dink & Dine Pickle Park
Dink & Dine in Mesa combines the excitement of pickleball with the comfort of great dining and social fun. Featuring 13 indoor and outdoor courts, the venue offers leagues, clinics, and tournaments for all skill levels, alongside a full menu of delicious food and drinks. With live music, family-friendly entertainment, and versatile event spaces, it’s a lively community hub where guests can play, eat, and connect.
Page Updated: 05/16/2026
*Prices and specials are subject to change at any time