Guadalupe on Main is a gluten-friendly Mexican restaurant and craft cocktail bar located on Main Street in Mesa. The restaurant specializes in flavors from Jalisco and operates as a craft kitchen with cocktails. Recently recognized by Phoenix Magazine as Best New Restaurant and Best Mexican Restaurant in their 2025 Best of the Valley awards. The establishment features a Chef's Test Kitchen and offers both dining and bar experiences.
Happy Hour
Specials
1/2 Bottles of Wine $1 Off Tacos Dorados $2 Off Drafts $3 Off Appetizers $4 Off Glasses of Wine $5 Select Cocktails
Amenities
Happy hours near Mesa
The Hub Grill & Bar - Stapley
The Hub Grill & Bar is a casual neighborhood restaurant and bar serving American comfort food with Southwest influences. The multi-location establishment features an extensive tap selection with domestic and craft beers, full bar service, and a menu that includes burgers, pizza, appetizers, and fish and chips. The venue offers gluten-free options and maintains a family-friendly atmosphere with kids eat free nights. Known for its consistent daily specials and happy hour programming, The Hub provides a relaxed setting for both dining and drinks.
Phantom Fox Beer Company
Phantom Fox Beer Company in Downtown Mesa is a community-driven brewery pouring 22 rotating craft beers on tap. The space blends a laid-back vibe with creative flavors, making it a welcoming stop for both casual sippers and craft beer enthusiasts. Guests can pair their drinks with nearby Goat and Ram Pizza, creating a perfect combination of local brews and bites. With daily happy hour specials and a friendly atmosphere, Phantom Fox is a standout in Mesa’s growing beer scene.
Espiritu
Espiritu Cocktails + Comida, located in Mesa, AZ, offers a vibrant dining experience with a focus on cocktails and Mexican cuisine. Opened by the teams behind Tacos Chiwas and Bacanora, Espiritu was named one of the best new restaurants in the country by Eater in 2022. The restaurant, known for its innovative take on Sonoran dishes and a lively atmosphere, offers a curated food menu and an extensive drinks list, earning acclaim for both its culinary and cocktail experiences.
Level 1 Arcade Bar
Level 1 Arcade Bar in Downtown Mesa is a lively destination where nostalgia and nightlife collide. Guests can enjoy over 100 rotating classic arcade games and pinball machines while sipping on craft beers and specialty cocktails. A full food menu keeps the energy going late into the night, paired with a soundtrack of 80s, 90s, and 2000s hits. With its vibrant atmosphere and ever-changing lineup of games, it’s a favorite spot for both casual outings and special events.
The Hub Grill & Bar - Sossaman
The Hub Grill & Bar is a casual neighborhood restaurant and bar serving American comfort food with Southwest influences. The multi-location establishment features an extensive tap selection with domestic and craft beers, full bar service, and a menu that includes burgers, pizza, appetizers, and fish and chips. The venue offers gluten-free options and maintains a family-friendly atmosphere with kids eat free nights. Known for its consistent daily specials and happy hour programming, The Hub provides a relaxed setting for both dining and drinks.
Arizona Distilling Co
Arizona Distilling Co. is a craft distillery located in Tempe, Arizona, dedicated to producing high-quality, small-batch spirits. They offer a range of products, including award-winning whiskeys, vodkas, and gins, all made using locally sourced ingredients and traditional distillation methods. With a commitment to excellence and a passion for craftsmanship, Arizona Distilling Co. provides a unique and authentic spirit experience, capturing the essence of Arizona's rich heritage and culture. Visitors can enjoy tours and tastings to learn more about the distillation process and sample their exceptional products.
Page Updated: 05/16/2026
*Prices and specials are subject to change at any time